Influence of Dietary Lipids on Glucuronidation and Sulfation of Phenol and Its para Substituent in the Rat

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概要

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• Rats were fed corn oil-free or corn oil-containing diets for 4 weeks to determine their effect on the competition between glucuronidation and sulfation in phenol and its para substituents. The activities of uridine diphosphate-glucuronyltransferase (UDPGT) on chemicals were enhanced with a 12% corn oil diet, whereas sulfotransferase activity showed no significant change. Following the intravenous injection of p-ethylphenol and p-tert-butylphenol, an increase of glucuronide and a decrease of sulfate were observed in the rats fed the corn oil diet. In contrast, no significant changes were observed in phenol and p-phenylphenol. These results are discussed in association with van der Waals volume (V_w) of substituent and phospholipid dependence of UDPGT.

• 公益社団法人日本薬学会の論文
• 1993-05-15

著者

• 南保 俊雄

  Tokai Research Laboratories Daiichi Pure Chemicals Co. Ltd.

• 南保 俊雄

  Daiichi Pure Chemicals Co., Ltd.,

関連論文

• The Effect of 4-Substituent of Benzoic Acid on Glycine Conjugation
• A Study on Thermostability of Immobilized Uridine Diphosphate-Glucouronyltransferase
• Phospholipid Dependency of Hepatic Uridine Diphosphate-Glucuronyltransferase in the Developing Fetus of the Rat
• Pharmacokinetics of p-Phenylbenzoic Acid in Near-Term Fetus of the Rat
• The Electronic Effects of Benzoic Acid Substituents on Glycine Conjugation
• Influence of Dietary Lipids on Glucuronidation and Sulfation of Phenol and Its para Substituent in the Rat
• The Relationship between Van der Waals Volume of 4-Substituent of Phenol and Sulfation in the Rat

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