Phospholipid Dependency of Hepatic Uridine Diphosphate-Glucuronyltransferase in the Developing Fetus of the Rat

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概要

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• The developmental change of uridine diphosphate-glucuronyltransferase (UDPGT) was studied using hepatic microsomes of rat fetuses on days 18 and 21 of gestation. Total phospholipid content was higher on day 21 than on day 18,although no significant difference in the composition between the two stages was observed. Lipid removal with phospholipase A_2 greatly reduced UDPGT activity for phenol in the later stage of gestation, even though the delipidation ratios in both stages were similar. The fluidity in the hydrocarbon region of the microsomal membrane was higher on day 21 than on day 18. No significant difference in the polarization of N-dansylaziridinyl protein was observed between the stages.

• 公益社団法人日本薬学会の論文
• 1991-09-25

著者

• 南保 俊雄

  第一化学薬品(株)東海研究所

• 南保 俊雄

  Tokai Research Laboratories Daiichi Pure Chemicals Co. Ltd.

• 南保 俊雄

  Tokai Research Laboratories, Daiichi Pure Chemicals Co., Ltd.,

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• A Study on Thermostability of Immobilized Uridine Diphosphate-Glucouronyltransferase
• Phospholipid Dependency of Hepatic Uridine Diphosphate-Glucuronyltransferase in the Developing Fetus of the Rat
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• Pharmacokinetics of p-Phenylbenzoic Acid in Near-Term Fetus of the Rat
• Cefuroximeの生体内運命に関する研究 (Cefuroxime(CXM))
• The Electronic Effects of Benzoic Acid Substituents on Glycine Conjugation
• Influence of Dietary Lipids on Glucuronidation and Sulfation of Phenol and Its para Substituent in the Rat
• The Relationship between Van der Waals Volume of 4-Substituent of Phenol and Sulfation in the Rat
• Advance on drug metabolism analysis method.

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