Identification and Determination of Glutathione and Glucuronide Conjugates Formed from Butylated Hydroxytoluene in Rats

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概要

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• Rats which had received butylated hydroxytoluene (BHT) excreted S- (3,5-di-tert-butyl-4-hydroxybenzyl) glutathione (BHT-glutathione) and 3,5-di-tert-butylhydroquinone (BHQ) glucuronide in the bile. After being separated by high-performance liquid chromatography, the glutathione conjugate was identified by ^<13>C-nuclear magnetic resonance and field desorption mass spectrometry ; the glucuronide was identified by gas chromatography-mass spectrometry. The structures of BHT-glutathione and BHQ glucuronide were further confirmed by comparison with synthetic samples. The excretion rates of BHT-glutathione and BHQ glucuronide in rat bile were 3.5 and 1.6%, respectively, of the dose in 24h after intraperitoneal administration of BHT at a dose of 400 mg/kg. The occurrence of BHT-glutathione suggests that 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone, a toxic metabolite of BHT, is detoxified by glutathione conjugation.

• 公益社団法人日本薬学会の論文
• 1983-10-25

著者

• 田島 和男

  北陸大・薬

• 山本 健次

  北陸大・外国語

• 水谷 民雄

  京都府大・生活科学

• 山本 健次

  School of Pharmacy, Hokuriku University

• 田島 和男

  School of Pharmacy, Hokuriku University

• 水谷 民雄

  Faculty of Living Science, Kyoto Prefectural University

• 水谷 民雄

  Faculty Of Living Science Kyoto Prefectural University

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