Further Metabolism of 3,5-Di-tert-butyl-4-hydroxybenzoic Acid, a Major Metabolite of Butylated Hydroxytoluene, in Rats

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概要

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• The metabolic pathway of butylated hydroxytoluene (BHT) to the ring-oxygenated metabolites 2,6-di-tert-butylhydroquinone (BHQ) and 2,6-di-tert-butyl-p-benzoquinone (BBQ) was examined in rats. After intraperitoneal administration of 3,5-di-tert-butyl-4-hydroxybenzoic acid (BHT-acid), which had been regarded as one of the major metabolic endproducts of BHT, 2,6-di-tert-butylphenol (DBP) and BBQ were identified in the feces by gas chromatography and gas chromatography-mass spectrometry (GC-MS). The biliary excretion of BBQ, BHQ glucuronide and BHT-acid glucuronide was also confirmed by GC-MS and high-performance liquid chromatography methods. The excretion rate of BHQ glucuronide for 24 h after dosing with BHT-acid was about 9-fold higher than that after dosing with BHT. In addition, the formation of BBQ was confirmed in the urine after dosing with DBP. These results suggest that BHT is metabolized to BHQ and BBQ through DBP formed by decarboxylation of BHT-acid.

• 公益社団法人日本薬学会の論文
• 1991-02-25

著者

• 田島 和男

  北陸大・薬

• 山本 健次

  北陸大・外国語

• 水谷 民雄

  京都府大・生活科学

• 山本 健次

  School of Pharmacy, Hokuriku University

• 田島 和男

  School of Pharmacy, Hokuriku University

• 竹村 麻里

  School of Pharmacy, Hokuriku University

• 水谷 民雄

  Faculty of Living Science, Kyoto Prefectural University

• 竹村 麻里

  School Of Pharmacy Hokuriku University

• 水谷 民雄

  Faculty Of Living Science Kyoto Prefectural University

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