Glycine Conjugation of the Substituted Benzoic Acids in Mice : Structure-Metabolism Relationship Study II
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概要
- 論文の詳細を見る
Glycine conjugation of a series of substituted benzoic acids was investigated in the mouse liver and kidney mitochondria. Correlations between the structure of 24 substituted benzoic acids and glycine conjugation were obtained. The extent of glycine conjugation of a series of substituted benzoic acids in liver mitochondria was different from that in kidney mitochondria. Glycine conjugation increased with greater lipid solubility in the mouse liver and kidney. The steric effect of the substituent had a far greater influence over the glycine conjugation in kidney, while the size of the substituent played a small role in the pattern of conjugation in liver. The formation of the glycine conjugate in liver was also dependent on the substituent electronegativity.
- 公益社団法人日本薬学会の論文
著者
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KASUYA Fumiyo
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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IGARASHI Kazuo
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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Kasuya F
Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University
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Kasuya Fumiyo
Department Of Toxicology Pharmaceutical Sciences Kobegakuin University
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Kasuya Fumiyo
Laboratory Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Kobegakuin University
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Igarashi Kazuo
Department Of Chemistry Virginia Polytechnic Institute And State University
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Igarashi K
Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University
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Igarashi Kazuo
Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University
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FUKUI Miyoshi
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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Fukui M
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Fukui Miyoshi
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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Kasuya Fumiyo
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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