Synthesis of 15-cis-(4-n-Propylcyclohexyl)-16,17,18,19,20-pentanor-9-deoxy-6,9α-nitriloprostaglandin F_1 Methyl Ester (OP-2507), a Novel Anti-cerebral Ischemic Agent

概要

論文の詳細を見る
Synthesized was 15-cis-(4-n-propylcyclohexyl)-16,17,18,19,20-pentanor-9-deoxy-6,9α-nitrilo-prostaglandin F_1 methyl ester (OP-2507), a novel, promising anti-cerebral ischemic agent. A key intermediate, methyl cis-4-n-propylcyclohexanecarboxylate, was prepared stereoselectively by the hydrogenation of methyl 4-n-propylbenzoate with commercially available dimer of chloro(1,5-cyclooctadiene)rhodium as a catalyst. Stereoselective reduction of C_<15>-ketone to C_<15α>-alcohol was achieved with diisobutylaluminum 2,6-di-tert-butyl-4-methylphenoxide.
社団法人日本薬学会の論文
1988-03-25