Potent orally Active Inhibitors of Angiotensin-Converting Enzyme (ACE)
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概要
- 論文の詳細を見る
1-[3-Mercaptoalkanoyl] pyroglutamic acids and 1-[3-mercaptoalkanoyl]-4-hetero (oxa, thia and aza) pyroglutamic acids were prepared and their inhibitory activities against angiotensin-converting enzyme (ACE) were examined. (2S)-1-[(2S)-3-Mercapto-2-methylpropanoyl] pyroglutamic acid 2 was found to be the most potent orally active inhibitor of ACE of rabbit lung among the derivatives synthesized in the present study and appeared to have great potential for use as an oral antihypertensive agent.
- 公益社団法人日本薬学会の論文
- 1981-08-25
著者
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林 正樹
Research Institute Ono Pharmaceutical Co. Ltd.
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今木 勝広
Central Research Institute, Ono Pharmaceutical Co., Ltd.
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作山 茂
Central Research Institute, Ono Pharmaceutical Co., Ltd.
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岡田 任功
Central Research Institute, Ono Pharmaceutical Co., Ltd.
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戸田 正明
Central Research Institute, Ono Pharmaceutical Co., Ltd.
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林 正樹
Central Research Institute, Ono Pharmaceutical Co., Ltd.
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宮本 積
Central Research Institute, Ono Pharmaceutical Co., Ltd.
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川崎 晃義
Central Research Institute, Ono Pharmaceutical Co., Ltd.
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桶川 忠夫
Central Research Institute, Ono Pharmaceutical Co., Ltd.
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作山 茂
Central Research Institute Ono Pharmaceutical Co. Ltd.
-
今木 勝広
Central Research Institute Ono Pharmaceutical Co. Ltd.
-
岡田 任功
Central Research Institute Ono Pharmaceutical Co. Ltd.
-
桶川 忠夫
Central Research Institute Ono Pharmaceutical Co. Ltd.
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