Structural Analogs of Leukotrienes C and D avd Their Contractile Activities

概要

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Thirteen structural analogs of leukotrienes C and D were prepared and tested for contractile activities on guinea pig pulmonary parenchymal strips. The analogs differed from the native structures in the peptide moiety, the 5-hydroxyl group, the carboxyl group and in the number and geometry of ethylenic bonds. Deamino analogs of leukotriene C_4 (LTC_4) and leukotriene D_4 (LTD_4) retained substantial contractile activities. Amide analogs of LTD_4 and 5-O-methyl-LTC_4 showed some activity. Modification of the peptide moiety caused a 1-3 orders of magnitude decrement. Analogs in which the various ethylenic bonds were saturated retained substantial contractile activity. However, perhydro LTD had no contractile activity.
公益社団法人日本薬学会の論文
1982-07-25