Conformational Changes in Fused Hydrazines, 2,3,5,10-Tetrahydro-1H-pyrazolo [1,2-b] phthalazines
スポンサーリンク
概要
- 論文の詳細を見る
Conformational changes of 2,3,5,10-tetrahydro-1H-pyrazolo [1,2-b] phthalazines (Va, Vb), which have a 6/5 fused ring system with two bridgehead nitrogen atoms, were studied by means of variable-temperature nuclear magnetic resonance (NMR) spectroscopy. It is concluded that they exist as the conformer VI with trans-fused configuration, converting between the two antipodes (IX, IX') via synchronous inversion of both nitrogens. The activation parameters (Ea, log A, ΔFc^*) for the inversion were also determined as follows. For Va ; Ea=16.9kcal/mole, log A=16.7,ΔFc^*=12.4 kcal/mole. For Vb ; Ea=18.7 kcal/mole, log A=18.3,ΔFc^*=12.5 kcal/mole.
- 公益社団法人日本薬学会の論文
- 1970-07-25
著者
関連論文
- Conformational Changes in Fused Hydrazines, 2,3,5,10-Tetrahydro-1H-pyrazolo [1,2-b] phthalazines
- Studies on Fused Hydrazines. IV. Some Rearrangement Reactions of 4-Methyl-2,3,5,10-tetrahydro-1H-pyrazolo [1,2-b] phthalazinium Iodide and Related Compounds to N-Aminoalkylisoindole or N-Aminoalkyl-pyrrole
- Studies on Fused Hydrazines. III. The Alkaline Decomposition of 2,3,5,10-Tetrahydro-1H-pyrazolo [1,2-b] phthalazine Methiodide and Related Compounds
- Studies on Fused Hydrazines. II. The Stevens-Type Rearrangement of 2,3,5,10-Tetrahydro-1H-pyrazolo [1,2-b] phthalazin-5-one Methiodide and Related Compounds
- Synthesis of 2,3,5,10-Tetrahydro-1H-pyrazolo[1,2-b]phthalazines
- Studies on Prototropic Tautomerism in Nitrogen Heterocyclic Compounds. II. A Ring-Chain Tautomerism in 3-Hydroxy-6-(2-oxocycloalkyl)-methyl-2(1H)-pyridone and 3-Hydroxy-6-(3-oxoalkyl)-2(1H)-pyridone Derivatives
- Studies on Prototropic Tautomerism in Nitrogen Heterocyclic Compounds. I. The Mannich Reaction of 2(1H)-Pyridone and 3-Hydroxy-2(1H)-pyridone
- Ring-Substituted α-Amino Acids. I. The Michael-type Addition of Maleic Hydrazide and Related Compounds leading to the α-Amino Acids.