キノン類の研究(第4報) : ナフトキノン誘導体と2-アミノチオフェノールの反応

概要

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Mechanism of the coloration reaction between 1,4-naphthoquinones and 2-aminothio-phenol in hydrochloric acidity was examined, 1,4-Naphthoquinone undergoes condensation with 2-aminothiophenol under dehydrogenation and dehydration to form 5H-benzo [a] phenothiazin-5-one, while 2-chloro- and 2,3-dichloro-1,4-naphthoquinone form the same 6-chloro-5H-benzo [a] phenothiazin-5-one by dehydrochlorinative and dehydrative condensation. 3-Chloro-2-methoxy-, 3-chloro-2-methyl-, and 2-(N-acetylanilino)-3-chloro-1,4-naphthoquinones also undergo dehydrochlorinative and dehydrative condensation. 1,4-Naphthoquinone, 2-chloro- and 2,3-dichloro-1,4-naphthoquinones react with excess of 2-aminothiophenol to form benzo [a]-1,4-benzothiazino [3,2-c] phenothiazine.
公益社団法人日本薬学会の論文
1970-02-25