キノン類の研究(第3報)ナフトキノン誘導体と酸ヒドラジドの反応

概要

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The mechanism of the coloration reaction of 1,2- and 1,4-naphthoquinone derivatives with acid hydrazides in alkali hydroxide solution was examined. The substitution occurs in the 4-position in 1,2-naphthoquinone-4-sulfonate, 3-chloro-1,2-naphthoquinone, 4-chloro-1,2-naphthoquinone and 1,2-naphthoquinone. In the 1,4-napthoquinone derivatives, coloration occurs by either substitution or addition in 2-chloro-1,4-naphthoquinone, 2-methoxy-1,4-naphthoquinone, 1,4-naphthoquinone-2-sulfonate, 2-methyl-1,4-naphthoquinone, 2-methyl-3-ch1oro-1,4-naphthoquinone, 2-methyl-3-methoxy-1,4-naphthoquinone, 2-chloro-3-methoxy-1,4-naphthoquinone, 2-chloro-3-acetoxy-1,4-naphthoquinone and 2-chloro-3-acetanilino-1,4-naphthoquinone. Unsubstituted acid hydrazides react with 1,4-naphthoquinones to show a more bathochromic coloration than the a-substituted acid hydrazides and it was assumed that this ia due to the possible enolization of the acid amide bonding of the reaction product.
公益社団法人日本薬学会の論文
1969-01-25