総合感冒剤中の主成分の定量法に関する研究(第8報) : チオシアン酸コバルトによるマレイン酸クロルフェニラミンおよび塩酸トリペレナミンの比色定量法

概要

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Colorimetric determination of Chlorpheniramine maleate (I) and Tripelennamine hydrochloride (II) in mixed anti-cold pharmaceutical preparations was examined, and a selective assay method was established. It is based on the formation of water-insoluble and organic solvent-soluble combaltothiocyanate complexes from aqueous solution of I and II. Each of these complexes is found to have the formula (Base・H)_2 [Co (NCS)_4]. The molar extinction coefficients (ε) of the complexes in CHCl_3 at 620 mμ (λ_<max>) are 1600 for Chloropheniramine maleate and 1620 for Tripelennamine hydrochloride. Assay method is as follows : To 2.0 ml of sample solution (I or II, 0.2-2 mg/ml) is added 10.0 ml of cobalt thiocyanate solution, prepared by dissolving 27.2 g of potassium thiocyanate, 20.4 g of cobalt nitrate, 13.6g of sodium acetate, and 10 ml of 1N hydrochloric acid in water to make 100 ml. After extracting the resulting complex with 10.0 ml of benzene, the extract solution is dried over anhydrous sodium sulfate, and absorbance is determined at 625 mμ. Standard solution is prepared in the same way.
公益社団法人日本薬学会の論文
1970-01-25