総合感冒剤中の主成分の定量法に関する研究(第9報) : 向流分配法の応用

概要

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In Craig-type countercurrent distribution, total quantity or material (Z) can be estimated by the equation derived from binomial distribution : [numerical formula] where W_1 W_2 and W_3 are the quantities of material in the peak tube and the one before and after the peak tube, respectively, K the partition coefficient, n the number of transfers, and γ the number of tubes. When binomial distribution can be approximated by normal distribution, Z can be estimated, independently of n, γ and K, by the following formula : [numerical formula] where W_<max> is the quantity of material in the peak tube, Wa(1) and Wa(2) are the quantities of material in the tubes of a-th before and after the peak tube respectively. Partition coefficients of chlorpheniramine maleate, dihydrocodeine phosphate, dlmethylephedrine hydrochloride, caffeine and 2-hydroxypropyl-7-theophylline were investigated, examined in several solvent systems, and they were found to be quantitatively separated with 50 transfers. By means of countercurrent separation followed by calculation of the total quantities of ingredients with above-mentioned equations, satisfactory results were obtained in separatory determination of mixed anti-cold pharmaceutical preparations.
公益社団法人日本薬学会の論文
1971-05-25