摘出水晶体に関する生化学的研究(第3報) : ナフタリン白内障の家兎水晶体にみられるカチオン濃度の変動

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Sodium, potassium and water contents in crystalline lens have been studied during the development of naphthalene cataract in rabbit. Cataract was developed in the following manner : first stage…vacuolar formation within 24-48 hours after naphthalene administration, second stage…opacity on the surface in 3-5 days, third stage…opacity and swelling of the cortex after 2 weeks, matured stage…complete cataract after 3-4 weeks. Potassium content in the lens decreased progressively with advancing stage from the first, and it was the contrary with sodium and water contents. Decrease of glycolytic activity of the lens was found after the second stage. Changes in electrophoretic pattern of soluble proteins and increase of insoluble proteins of the lens were not distinctly detected until the third stage. Marked decrease of β-crystalline content was observed in the matured stage. These results indicate that the development of naphthalene cataract is in intimate correlation with changes of cationic contents and hydration of lens. It might be reasonably assumed that inhibition of cation transport is the first biochemical change occuring in naphthalene cataract.
公益社団法人日本薬学会の論文
1969-06-25