摘出水晶体に関する生化学的研究(第2報) : 実験的白内障惹起物質のカチオン輸送阻害作用について

概要

論文の詳細を見る
Several cataractogenic compounds were studied, especially quinone compounds in detail, for their inhibitory action on active transport in rabbit lens surviving in vitro. 1,4-Benzoquinone, 1,2-naphthoquinone and vitamin K_3 inhibited cation transport and glycolysis in the lens, whereas coenzyme Q_7 did not. Hydroquinone and β-naphthol, the reduced form of 1,4-benzoquinone and 1,2-naphthoquinone, scarcely affected cation transport and glycolysis. Among the reducing substances found in the lens, ascorbic acid showed potent antagonistic action against 1,4-benzoquinone. CySH competed with 1,2-naphthoquinone slightly. GSH competed with 1,2-naphthoquinone certainly and with the other quinone compounds in less degree. 2,4-Dinitrophenol inhibited cation transport, but did not inhibit glycolysis. Alloxan had no effect on both responses.
公益社団法人日本薬学会の論文
1968-08-25