フラン誘導体の合成化学的研究(第48報) : Difurylfuro[2,3-d]pyrimidine類およびDifurylfuro[3,2-d]-s-triazolopyrimidine類の合成

概要

論文の詳細を見る
2-Amino-3-cyano-4,5-bis [2-furyl] furan (I), obtained from furoin and malononitrile, was reacted with carbon disulfide, formamide, and iminoethers, and 2-ethoxymethyleneamino-3-cyano-4,5-bis (2-furyl) furan (III), obtained from the reaction of I and ethyl orthoformate, was reacted with ammonia and hydrazine to obtain the corresponding difurylfuro[2,3-d] pyrimidines. 3-Amino-4-iminofuro[2,3-d]-3,4H-pyrimidine (XII) underwent rearrangement to 4-hydrazinodifurylfuro[2,3-d] pyrimidine (XIII) on being heated. Reaction of XII and XIII with ethyl orthoformate or acetic anydride afforded the corresponding furo[3,2-d]-s-triazolo[2,3-d] pyrimidines (XIV and XV) and furo[3,2-d] -s-triazolo[4,3-c]pyrimidines (XVI and XVII). Heating of XVI and XVII in pyrimidine effected their rearrangement to XIV and XV.
公益社団法人日本薬学会の論文
1969-10-25