2-ベンツイミダゾールチオール誘導体の研究 : (第5報)1-(Dialkylaminoalkyl)-2-(p-ethoxyphenylthio)benzimidazoleの鎮痛作用に関する構造活性相関

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概要

• 論文の詳細を見る

• 1-(2-Diethylaminoethyl)-2-(p-ethoxyphenylthio)benzimidazole (I) is considered to be a morphine-like analgesic and its derivatives, 1-(diethylaminoalkyl)-2-(p-ethoxyphenylthio) benzimidazoles, were synthesized to test their analgesic effect by the pressure method. Except for the 1-(2-pyrrolidinoethyl)derivative showing better activities than I or morphine, other derivatives did not show much effect, such as 1-diethylaminomethyl, 3-diethylaminopropyl, 1-[2-(allylamino)ethyl], 1-(2-dialkylaminopropyl), and 1-(1-methyl-2-piperidinoethyl) derivatives. The allyl derivative did not show any antagonistic action against I or morphine. Some discussions were made on the central atom, basic nitrogen, and the flat aromatic portion in the molecules of I and its analogs.

• 公益社団法人日本薬学会の論文
• 1967-03-25

著者

• 赤 輝也

  Research Laboratory, Taisho Pharmaceutical Co., Ltd.

• 赤 輝也

  Research Laboratory Taisho Pharmaceutical Co. Ltd.

• 赤 輝也

  大正製薬株式会社研究部

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• 2-ベンツイミダゾールチオール誘導体の研究(第4報) : 1-(2-Diethylaminoethyl)-2-(p-ethoxyphenylthio)-benzimidazole hydrochlorideの鎮痛作用ならびに一般薬理作用
• Syntheses and Activities of Bioquinone Substances. II. Ubichromenol Phosphates and Related Compounds
• 2-ベンツイミダゾールチオール誘導体の研究(第6報) : 1-(2-Diethylaminoethyl)-2-(p-ethoxyphenylthio)-5-substituted Benzimidazoleの合成および鎮痛効果
• 2-ベンツイミダゾールチオール誘導体の研究 : (第5報)1-(Dialkylaminoalkyl)-2-(p-ethoxyphenylthio)benzimidazoleの鎮痛作用に関する構造活性相関
• 2-ベンツイミダゾールチオール誘導体の研究(第3報) : 2-(ω-ヒドロキシ-, ω-アミノ-アルキル)-置換体ならびに, 1-(2-ジエチルアミノエチル)-2-クロロベンツイミダゾールの熱分解反応

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