2-ベンツイミダゾールチオール誘導体の研究(第4報) : 1-(2-Diethylaminoethyl)-2-(p-ethoxyphenylthio)-benzimidazole hydrochlorideの鎮痛作用ならびに一般薬理作用

概要

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Analgesic action and pharmacological properties of 1-(2-diethylaminoethyl)-2-(p-ethoxyphenylthio)benzimidazole monohydrochloride (I). I showed similar analgesic effect as morphine when tested by the pressure method and D'Amour-Smith method, but hypotensive and respiration inhibitive activities of I were stronger than those of morphine. Analgesic, hypotensive, and respiration inhibitory actions of I were antagonized by Levallorphan while I caused addiction in rats same as morphine. I also caused Straub's reaction in mice, same as morphine. In such a way, I has a morphine-like action and was proved to have pharmacological effects similar to narcotic analgesics in spite of the absence of any structural similarity.
公益社団法人日本薬学会の論文
1967-03-25