クロルシアン1-フェニル-3-メチル-5-ピラゾロン法によるマレイン酸クロルフェニラミンの比色定量法について

概要

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Application of cyanogen chloride and 1-phenyl-3-methyl-5-pyrazolone to chloropheniramine maleate results in reddish violet coloration and the solution has absorption maximum at 550 mμ. By using this coloration reaction, colorimetric determination of chloropheniramine maleate was examined and a sensitive method was established in which adverse effect of existing substances was minimized. By the use of this method, the usual substances compounded in ordinary cold cures such as sulpyrin, aminopyrine, acetylsalicylic acid, 4-hydroxyacetanilide, phenacetin, caffeine, guaiacol glycerol ether, methylephedrine hydrochloride, and dihydrocodeine phosphate would not interfere in the determination even if present in 75 volumes of chloropheniramine maleate, and noscapine in 15-fold amount. On the other hand, pyridoxine hydrochloride affects the determination even in 3-fold amount and riboflavine causes negative error if present in one-half the amount of chloropheniramine maleate. These interferences can be removed by extraction of chloropheniramine with petroleum ether in ammonia alkalinity. Concentration range of chloropheniramine maleate determinable by this method is 100〜500 μg./5 ml., and precision of measurement is σ^^^= 1.54% (n=6).
公益社団法人日本薬学会の論文
1967-03-25