ヒドロキシルアミン誘導体の合成研究(第1報) : 置換ヒドロキシルアミンを用いるMannich反応

概要

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Mannich reaction was carried out with the use of substituted hydroxylamines and 3,3"-(substituted benzyloximino)-4', 4"-bis (substituted) propiophenones (Table I), 3-(N-sub-stituted benzyloxy-substituted benzylamino)-4'-(substituted) propiophenones or 3-(N-alkoxy-alkylamino)-4'-(substituted) propiophenones (Table II), 3-(2-isoxazolidinyl)-4'-(substituted)-propiophenone, and 3-(tetrahydro-2H-1,2-oxazin-2-yl)-4'-(substituted) propiophenone, (Table III) were synthesized. Substituted hydroxylamines used included O-substituted and O, N-disubstituted hydroxylamines, isoxazolidines, and tetrahydro-1,2-isoxazine, and substituted acetophenone was used for the active methylene compound. Some of the compounds formed by this reaction were reduced with sodium borohydride and some α-[2-(substituted benzyloxy-substituted benzylamino) ethyl]-(para-substituted) benzyl alcohols and α-[2-(tetrahydro-2H-1,2-oxazin-2-yl) ethyl]-(para-substituted) benzyl alcohols (Table IV) were obtained.
社団法人日本薬学会の論文
1966-04-25