Antitumor Activity of 3-(Substituted cinnamoyl) pyridine and 1-Oxide
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概要
- 論文の詳細を見る
Some azachalcones (3-(substituted cinnamoyl) pyridine and its 1-oxide) were synthesized. Their antitumor activity on Yoshida sarcoma and rat ascites hepatoma AH-13,AH-66 and AH-7974 was determined. 2-Chloroazachalcone, 3-chloroazachalcone, 2-chloroazachalcone 1-oxide and 3-chloroazachalcone 1-oxide were found to be curative to AH-13,AH-66 and AH-7974 but negative to Yoshida sarcoma. A few experiments to elucidate the mechanism of antitumor effect of azachalcones were performed. Effects of 3-chloroazachalcone on the growth and on the content of DNA, RNA and protein of ascites hepatoma AH-66 was observed.
- 社団法人日本薬学会の論文
- 1970-07-25
著者
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入倉 勉
Kyorin Chemical Laboratory
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長谷川 嘉成
Kyorin Chemical Laboratory
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川崎 一
Kyorin Chemical Laboratory
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豊田 高明
Kyorin Chemical Laboratory
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遠田 良一
Kyorin Chemical Laboratory
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佐藤 志摩夫
Kyorin Chemical Laboratory
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