p-Phenylenediamineのラットにおける生体内分布, 排泄および代謝

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概要

• 論文の詳細を見る

• The distribution, excretion and metabolism of p-phenylenediamine, a constituent of oxidative hair dye, was studied after intraperitoneal administration of p-phenylenediamine-^<14>C (1.5 mg/kg) to male rats. In tissues other than the small and large intestines, the highest concentration of radioactivity was found at 1 hr, followed by a rapid decrease in concentration. Only small amounts of radioactivity were found in the tissues 48 hr after administration. The low levels of radioactivity in tissues, together with the large amounts of radioactivity found in the intestinal tract and in urine, indicated the rapid excretion of administered p-phenylenediamine. Within 24 hr after administration, 69% of the administered radioactivity was excreted in the urine, 29% in the feces, and 26% of the intravenously administered radioactivity was excreted in the bile. Thin-layer chromatography of the urine indicated the presence of several urinary metabolites. The reverse isotope dilution method identified one of the metabolites as N, N'-diacetyl-p-phenylenediamine, which accounted for 30% of the radioactivity in the urine.

• 社団法人日本薬学会の論文
• 1979-11-25

著者

• 中尾 美津男

  Hatano Research Institute, Food and Drug Safety Center

• 中尾 美津男

  Hatano Research Institute Food And Drug Safety Center

• 中尾 美津男

  財団法人食品薬品安全センター秦野研究所

• 武田 寧

  財団法人食品薬品安全センター秦野研究所

関連論文

• Regioselective N-Acetylation as a Route of Nitro-p-phenylenediamine Metabolism by Rat Liver Cytosol
• Metabolism of the Hair Dye Component, Nitro-p-phenylenediamine, in the Rat(Pharmacological)
• Reductive Metabolism of Nitro-p-Phenylenediamine by Rat Liver
• p-Phenylenediamineのラットにおける生体内分布, 排泄および代謝
• 酸化型染毛剤の突然変異性に関する研究(第1報)染毛剤原料の過酸化水素による酸化後の突然変異性について
• ニトロソアミンの生体内運命と代謝活性化

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