酸化型染毛剤の突然変異性に関する研究(第1報)染毛剤原料の過酸化水素による酸化後の突然変異性について

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Bacterial mutagenicity of five hair dye intermediates was examined after oxidation by hydrogen peroxide under alkaline condition (pH>10), using Salmonella typhimurium TA98 as the tester strain. Hair dye intermediates tested were p-phenylenediamine, p-toluylenediamine, o-nitro-p-phenylenediamine, and 2,4-diaminoanisole. In the case of oxidation of p-phenylenediamine, m-phenylenediamine, or 2,4-diaminoanisole, the mutagenic activity of aromatic diamine varied with the amine concentration in the reaction mixture. Similar effect was also observed with hydrogen peroxide. A lower mutagenic activity was observed when a lower concentration of amine or hydrogen peroxide was employed. Such a concentration effect was not significant in the oxidation of p-toluylenediamine and o-nitro-p-phenylenediamine. In the case of oxidation of amine mixtures, the derived mutagenic activity varied markedly with the molar ratio or the concentration of constituent amines. Therefore, the mutagenic activity of oxidative hair dyes might depend not only on the kind of hair dye intermediates in hair dye preparations, but also on their concentrations.
社団法人日本薬学会の論文
1978-12-31