Reductive Metabolism of Nitro-p-Phenylenediamine by Rat Liver

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概要

• 論文の詳細を見る

• Reductive metabolism of the hair dye constituent, nitro-p-phenylenediamine (2-nitro-1,4-diaminobenzene, NPDA), and its acetylated metabolite, NPDA N^4-acetate, was investigated with rat liver subcellular fractions, microsomes and cytosol. Under anaerobic conditions, these compounds were reduced to their corresponding amines by these fractions. The microsomal nitro-reducing activity was retarded completely by air and strongly by carbon monoxide. Reduced nicotinamide adenine dinucleotide phosphate (NADPH) functioned more effectively than reduced nicotinamide adenine dinucleotide (NADH) as an electron donor in the microsomal reduction of the nitro compounds, and flavin mononucleotide (FMN) gave rise to a marked enhancement in the microsomal activity, especially when added to an anaerobic incubation mixture containing both NADH and NADPH. The cytosolic nitro-reducing activity was attributed to xanthine oxidase, aldehyde oxidase and other unknown enzyme(s), based on the results of cofactor requirements and inhibition experiments.

• 社団法人日本薬学会の論文
• 1991-01-25

著者

• 中尾 美津男

  Hatano Research Institute, Food and Drug Safety Center

• 後藤 由紀子

  Hatano Research Institute, Food and Drug Safety Center

• 平塚 明

  Laboratory of Drug Metabolism and Toxicology, Department of Hygienic Chemistry, Tokyo College of Pha

• 中尾 美津男

  Hatano Research Institute Food And Drug Safety Center

• 渡辺 烈

  Laboratory of Drug Metabolism and Toxicology, Department of Hygienic Chemistry, Tokyo College of Pha

• 渡辺 烈

  Laboratory Of Drug Metabolism And Toxicology Department Of Hygienic Chemistry Tokyo College Of Pharm

• 平塚 明

  Laboratory Of Drug Metabolism And Toxicology Department Of Hygienic Chemistry Tokyo College Of Pharm

• 後藤 由紀子

  Hatano Research Institute Food And Drug Safety Center

関連論文

• Regioselective N-Acetylation as a Route of Nitro-p-phenylenediamine Metabolism by Rat Liver Cytosol
• Metabolism of the Hair Dye Component, Nitro-p-phenylenediamine, in the Rat(Pharmacological)
• Mechanism of Species Difference in N-Hydroxyphenacetin Mutagenicity : The Role of Deacetylation by Rat and Hamster Liver Microsomes
• Reductive Metabolism of Nitro-p-Phenylenediamine by Rat Liver
• p-Phenylenediamineのラットにおける生体内分布, 排泄および代謝
• Solubilization of Epoxide Hydrolase from Liver Microsomes

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