Chloroquineの家兎尿中排泄における塩化アンモニウムの効果

概要

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The effect of ammonium chloride on urinary excretion of chloroquine (CQ) was examined in the rabbit. Volume, pH and CQ content of the urine were measured every day for 2 weeks. The animals were divided into two groups. One group of animals were given CQ diphosphate, 30 mg/kg/day (s.c.), during the 2 weeks, and one-half of these animals were given NH_4Cl (ca. 0.5 g/kg/day, oral) during the second week, when they excreted 2-4 times the amount of CQ excreted by the animals not given NH_4Cl throughout. The other group of animals were given CQ during the first week only, and one-half of these animals were given NH_4Cl during the second week. During the CQ treatment, the daily urine volume was much more variable and 2-3 times less than that excreted after cessation of CQ treatment. NH_4Cl affected neither the urine volume nor the amount of CQ excreted. pH of the urine excreted during NH_4Cl treatment (6.29-6.91) was lower than that excreted during the control period (7.25-8.57). These results indicate that NH_4Cl facilitates urinary excretion of CQ only when given simultaneously with CQ, and may suggest a possibility that CQ caused a kidney dysfunction.
公益社団法人日本薬学会の論文
1977-09-25