増感作用の薬理学的研究(第3報)モルモット摘出気管標本に対する増感物質の作用

概要

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Dose-response relationship of the effect of various potentiators to contraction and relaxation of isolated tracheal preparation of a guinea pig was examined and following results were obtained. (1) Cocaine augmented both contraction and relaxation induced by norepinephrine or epinephrine, but relaxation induced by aminophylline or papaverine was not influenced and that by isoproterenol or trimetoquinol decreased by cocaine. (2) Relaxation induced by norepinephrine or epinephrine was potentiated by chlorpromazine, phentolamine, and Dibenamine, while contractile responses induced by these catecholamines were not influenced by chlorpromazine, and abolished by phentolamine and Dibenamine at the same concentration range for inducing a dose-dependent augmentation of relaxation. This indicates that adrenergic α-blocking activity of these potentiators does not contribute to the augmentation of relaxation induced by catecholamines. (3) Cocaine also increased the sensitivity of tracheal preparation to acetylcholine without any effect on the level of maximum response, but dose-response relationship of cocaine for the potentiation of response to acetylcholine was not coincident to that to norepinephrine. (4) Higher concentration of cocaine decreased the level of maximum response of tracheal preparation to acetylcholine in low-calcium medium, but the mechanism of this inhibitory action remains unsolved.
公益社団法人日本薬学会の論文
1976-03-25