SH-SS交換反応による2-メルカプトプロピオニルグリシンおよびペニシラミンの酸化還元電位に関する研究

概要

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Relative oxidation-reduction potentials were obtained from the study on the equilibrium of 2-mercaptopropionylglycine-cysteine and -glutathione systems. CSSC(GSSG)+MPGSH=CS-SMPG(GS-SMPG)+CSH(GSH) CS-SMPG(GS-SMPG)+MPGSH=(MPGS-)_2+CSH(GSH) CSSC(GSSG)+(MPGS-)_2=2CS-SMPG(2GS-SMPG) CSSC(GSSG)+2MPGSH=(MPGS-)_2+2CSH(2GSH) where CSH, GSH, and MPGSH represent cysteine, glutathione and 2-mercaptopropionylglycine (reductant), and CSSC, GSSG and (MPGS-)_2 are their disulfide forms (oxidant), respectively. Penicillamine (PSH) was also employed as another reductant. The relative oxidation-reduction potentials obtained were as follows : E(MPGSH)-E(CSH)=-0.029V, E(MPGSH)-E(GSH)=-0.015V, E(PSH)-E(CSH)=0.032V, E(PSH)-E(GSH)=0.046 V. Thus the order of reducing activity was MPGSH>GSH>CSH>PSH. Rate constants for the exchange reaction of MPGSH with CSSC were also studied.
公益社団法人日本薬学会の論文
1974-06-25