各種リン酸ナトリウムとフッ化ナトリウムの反応によるモノフルオロリン酸ナトリウムの生成

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Sodium monofluorophosphate (I) was prepared by the reaction of sodium fluoride with various sodium phosphates, the reaction conditions and difference in the amount of I according to the starting material used were examined, and the results were as follows : (1) Although I is not formed by the reaction of NaF with sodium ortho-, pyro-, or tripoly- phospates, it can be produced from these phosphates when P_2O_5 was added, even at such a low temperature as 200°.(2) In the case of chain polyphosphates, the amount of I produced increases with the chain length, but its yield becomes almost constant when n^^- is longer than 12.(3) In case of ring phosphates, I is readily produced, and sodium tetrametaphosphate can give I in a better yield than sodium trimetaphosphate. (4) The reaction of a mixture of NaF, P_2O_5,and Na_2CO_3 gives I in a good yield, and a mixture of NaF and P_2O_5 also gives I but contaminated with impurities. These results show that the yield of I varies according to the phosphates used as the starting material, heating temperature, and heating time. The optimum condition for preparing I seems to be to heat for a short time (6 min) at a high temperature (700-800°) when long-chain (n^^-≧12) or ring phosphates are used, and to add P_2O_5 and heat for a long time (60 min) at a low temperature (300-500° in case of the orthophosphate, 600° in case of pyro- and tripoly-phosphates) when short-chain polyphosphates are used. Further, I can also be prepared by heating a mixture of P_2O_5,Na_2CO_3,and NaF.
社団法人日本薬学会の論文
1974-04-25

各種リン酸ナトリウムとフッ化ナトリウムの反応によるモノフルオロリン酸ナトリウムの生成

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