Reaction of Trimetaphosphate with Glycine

概要

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The reaction of trimetaphosphate (P_<3m>) with glycine in an aqueous solution was studied. 1) P_<3m> reacted with glycine at pH 10 and above to form two unknown compounds, A and B. 2) The amounts of these compounds were strongly affected by reaction conditions, such as the mixing ratio of P_<3m> and glycine and the pH, and the yields of compounds A and B were around 26 and 24%, respectively. 3) Compound A was proved to be an orthophosphate derivative of glycine (P_1-derivative of glycine), aminoacetyl phosphate, [chemical formula], while compound B was found to be a P_1-derivative of glycine, N-(carboxymethyl) phosphoramidate, [chemical formula]. 4) It was found that glycylglycine (dimer), glycylglycylglycine (trimer), and higher oligopeptides of glycine were formed in the reaction of P_<3m> and glycine. Further, in the reaction at pH 10-14,tetra-(P_4) and pentaphosphate (P_5) were also formed besides compounds A and B, though in small quantities. 5) Short-chain phosphates, such as ortho-(P_1), pyro-(P_2) and triphosphate (P_3), did not react with glycine at all. 6) The mechanism of the reaction of P_<3m> with glycine is discussed.
公益社団法人日本薬学会の論文
1982-11-25