Mesitylenesulfonyl化によるナフチルアミンの高速液体クロマトグラフィー

概要

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The trace amount of β-naphthylamine (β-NA) co-existing with a large amount of α-naphthylamine (α-NA) was determined with high accuracy and sensitivity by high speed liquid chromatography after mesitylenesulfonylation (Ms-). By elution with methanol/acetonitrile/pH 4.6,0.1M sodium acetate buffer (54 : 6 : 40 v/v) on an ODS column, the resolution between Ms-α-NA and Ms-β-NA peaks was 3.43. A more accurate detection of Ms-β-NA than of Ms-α-NA was possible at approximately 240 nm using an ultraviolet monitor. With this method, the amount of Ms-β-NA was determined within 1.1% error over the range from 0.005 to 10μg, and the limit of detection was 0.005μg.
社団法人日本薬学会の論文
1980-04-25