テオフィリンとトリメチレンジアミンとの固体複合体

概要

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Solid complex of theophyline and trimethylenediamine was examined by X-ray diffraction, differential thermobalance, and infrared spectrophotometry, and it was found that theophylline and trimethylenediamine formed a solid complex in 2 : 1 molar ratio in absolute ethanol. This complex contains 1 mol of crystal water. The binding of theophyline and ethylenediamine was considered to be the same as in the case of aminophylline. Differential thermoanalysis of the solid complex in air with thermobalance, at the rate of 2.5°/min temperature rise, showed that weight loss begins at around 80°, accompanied with endothermic peaks, with appearance of a small endothermic peak at around 102°, large endothermic peak at around 122°, and an endothermic peak shoulder at around 128°, resulting in the completion of thermal change and weight loss at around 136°. These phenomena may be explained by two routes of thermal decomposition ; one of simultaneous liberation of the crystal water and trimethylenediamine to form anhydrous theophylline, and the other of formation of an anhydrous solid complex by the release of crystal water, followed by liberation of trimethylenediamine to form anhydrous theophylline, and the observed endothermic peaks were the overlap of these thermal reactions.
公益社団法人日本薬学会の論文
1980-02-25