γ-グルタミルトランスペプチダーゼの糖鎖-そのがん性変化と診断への応用

概要

論文の詳細を見る
Studies of γ-glutamyltranspeptidases purified from a variety of organs of several mammals revealed that organ- as well as species-specific differences exist in their sugar moieties. Comparative studies of the two subunits and various isozymic forms of the rat kidney enzyme revealed that high mannose-type sugar chains are included only in the large subunit and the difference in the numbers of acidic sugar chains is the molecular bases of the isozymic forms of the enzyme. Comparative study of the enzymes purified from rat liver and rat AH-66 hepatoma indicated that several structural differences exist in the sugar chains of the two enzymes. Among them, occurrence of bisecting GlcNAc residue in half of the sugar chains of hepatoma is most important because the residue is never found in the sugar chains of glycoproteins including γ-glutamyltranspeptidase produced in normal liver. By making used of the change, a new method for the diagnosis of hepatoma has been developed.
公益社団法人日本薬学会の論文
1984-08-25