回転籠法によるマウス自発運動の行動薬理学的研究
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概要
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Effects of methamphetamine, methylphenidate, caffeine, and diazepam on wheel-running activity of mice well accustomed to the wheel cage were investigated. In this study, "continuous running (CR)" was used as a parameter of a unit behavior of mice and a method of quantitative measurement and analysis of drug-induced changes in the running activity which could not be carried out by the conventional method measuring only the number of revolutions of the wheel cage has been developed. 1) Turning time per revolution of the wheel cage was automatically recorded. A series of wheel-running activity consisting of revolutions less than 1.0s, a critical time, was defined as CR and the number of revolutions in the series of activity was called the distance of CR. For the evaluation of the effects of drugs on wheel-running activity of mice, the following measures were used : the number of revolutions, the frequency of CRs, and the mean distance of CR, respectively in a given time. The quantitative relationship among these three measures is as follows : the product of the mean distance of CR and the frequency of CRs is equal to the number of revolutions. 2) Methamphetamine (2.0 mg/kg, s.c.) and methylphenidate (10.0 mg/kg, s.c.) caused a significant increase in the frequency of CRs and a significant decrease in the mean distance of CR. Methylphenidate also increased the number of rovolutions. Caffeine (10.0 mg/kg, s.c.) had no significant effect on these three parameters. Diazepam (2.5 mg/kg, s.c.) increased significantly the mean distance of CR, while it decreased significantly the frequency of CRs without any changes in the number of revolutions.
- 公益社団法人日本薬学会の論文
- 1984-06-25