カラゲニン炎症(第1報)ラット胸腔内投与における循環器障害と形態学的特徴

概要

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In order to obtain an experimental inflammatory model for the evaluation of various antiphlogistics, λ-carrageenin was employed and the results of the histological changes in rats injected 1% λ-carrageenin into the pleural cavity were mainly reported. In addition, for the purpose of elucidating the damage to the gastric mucosa, an experimental gastric erosion was brought about in the rats by the oral administration of 100 mg/kg of aspirin, 3% acetic acid, 1% λ-carrageenin, and an injection of 1% λ-carrageenin into the pleural cavity. The stomach of these rats in an artificial gastric juice was incubated. The rats injected with λ-carrageenin decreased remarkably in body weight, and in the weight of their lungs, heart and thymus. However, the liver increased in weight. Fibrin clots were histologically found on the pleural surface at the injected side, along with significant congestion associated with neutrophils and lymphocytes infiltration in the liver and spleen. The results concerning the measurement of tyrosine suggested undoubtable damage to the mucosa of stomach administered λ-carrageenin. Thus, this model is useful for estimating the various antiphlogistic efficacies.
公益社団法人日本薬学会の論文
1983-07-25