漢方方剤"補中益気湯"の骨髄障害防御作用と感染防御効果

概要

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Effect of Hochu-ekki-to (HET) on the number of peripheral leukocytes (PL) and their functions in cyclophosphamide (CY)-treated or γ ray-irradiated mice was investigated. By treatment of mice with anticancer agent CY or γ ray irradiation, unfavorable side effects usually occured to impair hematopoietic organs, causing bone marrow disorder. However, it was significantly protected by oral administration of HET (1 g/kg/d) to CY-treated or γ ray-irradiated mice. The numbers of neutrophils and monocytes in PL were restored to the normal level, and colony-stimulating factor (CSF) was induced in the sera of mice by HET in a dose-dependent manner. The induction of serum CSF reached a peak at 3h after HET administration. Colony-forming unit of bone marrow cells in the spleen adoptively transfered into syngeneic mice, that is defined as CFU-S, was extremely reduced by CY-treatment. However, when HET was orally administered, CFU-S of CY-treated mice was markedly stimulated, suggesting that bone marrow cells were reactivated for further proliferation and mobilization. HET enhanced other leukocyte functions in CY-treated mice; i.e., superoxide production of neutrophils and phagocytic activity of macrophages. Thus, oral administration of HET to CY-treated mice enforced protection against Pseudomonas aeruginosa infection.
社団法人日本薬学会の論文
1990-09-25