偏光顕微鏡による結晶性医薬品の研究(第11報)散剤中の主薬の粒度分析, フェニトイン10倍散の場合

概要

論文の詳細を見る
By the immersion method with a polarizing microscope a principal agent phenytoin was identified from its 10 times trituration containing vehicles such as lactose and starch. A particle size distribution of phenytoin crystals in its trituration was determined by observing one of the habit parameters b from all the detectable particles of phenytoin under a microscope in a suspension of an immersion oil, n_D : 1.555,in which phenytoin crystals having key refractive indexes, n_1 : 1.606,n_2 : 1.631,were clearly detectable from other vehicles. By the similarity of crystal habits in the same lot the particle size distribution of phenytoin crystals in its trituration was calculated from the values of observed parameter b and average values of habit coefficients, T (√<ab/c>) : 2.004,L (b/a) : 2.545,which were obtained from some previously identified phenytoin crystals.
社団法人日本薬学会の論文
1990-07-25