偏光顕微鏡による結晶性医薬品の研究(第15報)写真法を用いる浸液法による必要な結晶特性の定常的測定(その1)

概要

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To obtain necessary characterizations of crystals, such as an extinction angle, an elongation, refractive indices and a birefringence, several polarizing photomicrographs taken under definite conditions by the immersion method using a kit of immersion oils prepared at intervals of 0.005 between n_D 1.470-1.730 were found to be useful enough. A standard procedure to take the least sheets of necessary photomicrographs using the known key refractive indices was proposed, and 8 kinds of crystalline drugs of which key refractive indices had been measured definitely (group A) except the last one showing only one key refractive index (group B) were tested together. It was also found that habit parameters as well as habit coefficients useful to obtain a particle size distribution were easily measured from orthographic projections produced from colored photomicrographs and the above obtained birefringences.
社団法人日本薬学会の論文
1995-04-25