偏光顕微鏡による結晶性医薬品の研究(第10報) : フェニトイン粉末の粒度分析

概要

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Particle size distributions of 2 kinds of phenytoin were studied using a polarizing microscope by the immersion method. Both phenytoins, a commercial JPX product, (A), and a special grade reagent, (B), had the same key refractive indices and similar habits of plates, though sizes of particles were quite different. Using a polarizing microscope the shapes of larger crystals and the patterns of their retardation colors, from which the thicknesses were to be measured, were quantitatively sketched. Then the habit parameters a, b and c (thickness) were determined from the sketched crystals, and the habit coefficients, K=√<ab>/c, L=b/a, were calculated. The habit parameters of the other smaller crystal grains, which had similar habits as the sketched crystals, were calculated from the measured parameter b using the habit coefficients. Finally, an approximate volume of an each particle, V=abc, and the total weight of all the crystal grains belonging to the limitted range of log V were calculated. The particle size distribution was shown as the correlation between the value of log V (abscissa) and the weight percent of the crystal grains belonging to an each limitted range of log V (ordinate).
社団法人日本薬学会の論文
1988-07-25