Open Field法によるMethamphetamine常同行動の解析と抗精神病薬の作用評価への応用
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The methamphetamine-induced stereotypy of mice in a three-dimensional open field divided into nine unit spaces was visually observed. Each space was a little larger in size than the mice. The resultant positional behaviors were analyzed by use of four measures, namely, total frequency of visits to unit spaces (N), spacial distribution of the animal location (H_1) obtained by the equation H_1=-Σ__ip_ilog_2p_i (bits), where p_i was the frequency of visits to a unit space numbered as i/N, approximated visit direction (H_<II>) obtained by the equation H_<II>=-Σ__<i, j>p_ip_<ij>log_2p_<ij> (bits), where p_<ij> was the frequency of visits from the i unit space to a unit space numbered as j/frequency of visits to the i unit space, and visit direction from the 6th unit space (H_<6→>) obtained by the equation H_<6→>=-Σ__jp_<6j>log_2p_<6j> (bits), where p_<6j> was the frequency of visits from the 6th unit space to the j unit space/frequency of visits to the 6th unit space. By increasing N methamphetamine gave and maximum effect at 2-4 mg/kg, s.c., but dose-dependently reduced the entropies, that is, H_I, H_<II> and H_<6→>. Haloperidol (0.1-1 mg/kg, p.o.), metoclopramide (1-10 mg/kg, p.o), chlorpromazine (3-30 mg/kg, p.o.) and sulpiride (1-100 mg/kg, i.p.) dose-dependently antagonized the methamphetamine (8 mg/kg, s.c.)-induced stereotypy. These results suggest that the present method is useful for the analysis of stereotypy and a better understanding of pharmacological activities of antipsychotic drugs.
- 公益社団法人日本薬学会の論文
- 1985-08-25
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