エタノール注入法によるリポソームの基礎的研究粒子径分布における添加剤の効果

概要

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Single bilayer liposomes (SUV type) were prepared by the injection method of ethanol solution of egg lecithin. Particle sizes of the liposome were measured at 25℃ by submicron particle sizer (Malvern) at intervals of a few days to know effects of several additives such as macrogol, soybean oil and DL-α-tocopheryl acetate, under the conditions that homogeneous and stable liposomes are obtained without additives. The particle size became smaller by the addition of macrogol and the liposome became more stable by the addition of soybean oil. The amount of DL-α-tocopheryl acetate in liposome solutions was found to be very high. The peak value at particle size distribution obtained from particle sizer coincided with that from the transmission electron micrographs.
社団法人日本薬学会の論文
1985-03-25