Rhubarb Use in Patients Treated with Kampo Medicines : A Risk for Gastric Cancer?
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概要
- 論文の詳細を見る
In vitro mutagenic effects have been reported for ingredients contained in rhubarb. Therefore, rhubarb (Rhei Rhizoma) as an anthranoid laxative could be associated with a risk of developing gastric cancer as well as colorectal cancer. We are not aware of any reports that have examined the relationship between the use of rhubarb and the development of gastric cancer. During the period between 1979 and 1999, we treated 14616 patients using various Kampo medicines, which sometimes contained rhubarb. In the present study, we determined whether patients, diagnosed with gastric cancer during the period between 1979 and 1999, had been administered rhubarb before the development of gastric cancer. Among the 10 enrolled patients, only 2 patients had been administered rhubarb before the development of gastric carcinoma. The other 8 patients had never received rhubarb before the development of gastric carcinoma. Rhubarb use may have little connection with the development of gastric cancer in practice, even if some ingredients in rhubarb have shown carcinogenic activity in experimental studies.
- 公益社団法人日本薬学会の論文
- 2002-06-01
著者
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萬谷 直樹
群馬大学医学部統合和漢診療学
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酒井 伸也
富山大学和漢医薬学総合研究所漢方診断学部門
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酒井 伸也
富山医科薬科大学 医学部 和漢診療学 講座
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寺澤 捷年
Department of Sino-Japanese (Kampoh) Medicine, University Hospital,Toyama Medical and Pharmaceutical
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萬谷 直樹
Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, Toyama Medical and Pharmaceut
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関矢 信康
Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, Toyama Medical and Pharmaceut
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酒井 伸也
Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, Toyama Medical and Pharmaceut
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小暮 敏明
Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, Toyama Medical and Pharmaceut
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嶋田 豊
Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, Toyama Medical and Pharmaceut
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