界面活性剤の突然変異原性に関する研究各種肝ホモジネート分画(S-9)を用いた代謝活性化試験およびNorharman共存下での変異原性試験

概要

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In this study, mutagenic potential of nine main surfactants after activation with various liver homogenates (S-9) was examined by using Salmonella typhimurium TA98 and TA100. Polychlorinated biphenyls (PCB), phenobarbital (PB) and 3-methylcholanthrene (3-MC) were used as inducers, and the S-9 fractions of livers of rats, hamsters and guinea pigs were used for this test. Further, mutagenicity of these surfactants in the presence of norharman (comutagen) was also examined. It was suggested that no surfactants used in this study were mutagenic on the strains of TA98 and TA100 in this test systems.
公益社団法人日本薬学会の論文
1981-08-31