Effect of Intraperitoneal Injection of Vibrio parahaemolyticus on the Carbohydrate Metabolism in Mice

概要

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The effects of intraperitoneal administration of Vibrio parahaemolyticus pathogenic strain on carbohydrate metabolism in mice at varying administration doses were examined. The content of liver glycogen in mice at 5 hr after injection decreased in inverse proportion to the increase of the dose of viable pathogen. On the other hand, the level of blood sugar in mice changed effectively with an increase in the dose, and at the dose of 0.8 mg (2.72×10^5 cells) a distinct hypoglycemia appeared within 5 hr after injection. The activities of hepatic phosphorylase and G-6-Pase showed a tendency similar to the rise and the fall in the levels of blood sugar. The result of this experiment suggests a complexicity of metabolic response in host to the aggression of pathogen.
公益社団法人日本薬学会の論文
1977-12-31