Effect of Intraperitoneal Administration of Vibrio parahaemolyticus on Serum Lipid Level in Mice

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Serum lipid level was investigated in mice by the intraperitoneal injection of Vibrio parahaemolyticus. At a sublethal dose (0.3 mg wet cells) a considerable increase in triglyceride content was observed in mouse serum at 1 day postinjection. In total cholesterol levels no appreciable difference was shown between the control and injected groups. However, serum triglyceride level in mice injected with nonpathogenic strain also increased in serum at 4 hr postinjection similarly to that injected with pathogenic strain. Serum triglyceride level in mice changed effectively with increasing doses (0.2-0.8 mg) of the microorganism, and a marked increase of the level at 6 hr postinjection was seen in the injected animals with an increase in doses, but total cholesterol levels did not change in both the control and injected groups. The heatstable hemolysin from pathogenic strain could not cause an appreciable change in triglyceride level in mouse serum. When Vibrio parahaemolyticus was administered into mice and after ten minutes the endotoxin antiserum was injected, the triglyceride content in serum was not different from that of the control mice. Judging from the hypertriglyceridemia of mouse by the endotoxin in the previous report and the results in the present study, it is presumed that the endotoxin is responsible for the increase in serum triglyceride level in mice injected with Vibrio parahaemolyticus pathogenic strain.
公益社団法人日本薬学会の論文
1977-04-30

Effect of Intraperitoneal Administration of Vibrio parahaemolyticus on Serum Lipid Level in Mice

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