Hepatic Glycogen Metabolism in Mice injected with Vibrio parahaemolyticus Endotoxin

概要

論文の詳細を見る
Changes of some metabolite and enzyme activities concerned with hepatic glycogen metabolism in mice were investigated by the intraperitoneal injection of endotoxin extracted from Vibrio parahaemolyticus. A marked depletion of hepatic glycogen, a considerable increase in blood sugar and a remarkable increase in blood-lactic acid amount were observed in the poisond mice 1-3 hr postintoxication. There was an increase in the activities of hepatic phosphorylase and G-6-Pase at 1 hr postintoxication, but the latter activity decreased thereafter. Hyperglycemia of mice was found in proportion to the dose of endotoxin, but mice injected with a large quantity (40 mg/kg) of endotoxin showed evident hypoglycemia after 16 hr.
公益社団法人日本薬学会の論文
1976-04-30