Effect of Carbon Tetrachloride on 3'-AMP- Forming Enzyme Activity in Rat Liver
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概要
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The effect of carbon tetrachloride (CCl_4) on adenosine 3'-monophosphate (3'-AMP) content and 3'-AMP-forming enzyme activity in rat liver was examined. The levels of 3'-AMP and the total amounts of adenosine 5'-triphosphate, adenosine 5'-diphosphate and adenosine 5'-monophosphate were decreased by treatment with CCl_4. The 3'-AMP-forming enzyme activity in CCl_4-treated rat liver homogenate was Ca. 4-fold higher than that of control. The enzyme activity in CCl_4-treated mitochondria was Ca. 50% of control values. These results suggest that the increase in the 3'-AMP-forming enzyme activity in the cytosol may be, at least partly, due to the leakage of the enzyme activity from mitochondria in acute hepatitis induced by CCl_4.
- 公益社団法人日本薬学会の論文
- 2002-04-01
著者
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PAN-HOU Hidemitsu
Faculty of Pharmaceutical Sciences, Setsunan University
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FUJIMORI Hiroyuki
Faculty of Pharmaceutical Sciences, Setsunan University
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Pan-hou Hidemitsu
Facul.of Pharm.sci. Setsunan Univ.
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Fujimori Hiroyuki
Faculty Of Pharmaceutical Sciences Setsunan University
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