Effects of Intrathecally Injected Glutamate and Substance P Antagonists on Repeated Cold Stress-Induced Hyperalgesia in Rats
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概要
- 論文の詳細を見る
To determine the role of NK-1 substance P receptors and N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptors in the spinal dorsal horn in the hyperalgesia induced by repeated cold stress (RCS), we examined the effects of intrathecal injections of antagonists to NK-1,NMDA and non-NMDA receptors on the nociceptive threshold of RCS rats for paw-pressure stimulation. Intrathecal injections of the NK-1 antagonist (2S, 3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)-methyl]-1-azabicyclo [2. 2. 2] octan-3-amine (CP-96,345,0.3-3 nmol/rat), the NMDA antagonist 2-amino-5-phosphonovaleric acid (APV, 1-10 nmol/rat), and the non-NMDA antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 1-10 nmol/rat) suppressed RCS-induced hyperalgesia in a dose-dependent manner, without affecting the nociceptive threshold of normal rats. Combinations of any two of CP-96,345 (3 nmol/rat), APV (10 nmol/rat), and CNQX (10 nmol/rat) did not produce a larger inhibition than that produced by their single doses. The present results suggest that the enhancement of the substance P-NK-1 receptor system and glutamate-NMDA and non-NMDA receptor systems in the spinal dorsal horn is at least partly involved in the RCS-induced hyperalgesia.
- 社団法人日本薬学会の論文
- 1995-01-15
著者
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倉石 泰
Department Of Applied Biochemistry Research Institute For Wakan-yaku Toyama Medical And Pharmaceutic
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岡野 一彦
Department of Pharmacology Faculty of Pharmaceutical Sciences, Kyoto University
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佐藤 公道
Department of Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University
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岡野 一彦
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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佐藤 公道
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Satoh M
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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佐藤 公道
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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