Effect of Vinconate on Long-Term Potentiation in a Mossy Fiber-CA3 System of Guinea Pig Hippocampal Slices

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概要

• 論文の詳細を見る

• We investigated the effect of vinconate on the long-term potentiation of population spikes following the stimulation of mossy fibers in the CA3 pyramidal layer of hippocampal slices from guinea pig brain. Vinconate (10^<-7> and 10^<-6> M) dose-dependently augmented the long-term potentiation in the mossy fiber-CA3 system. This effect was reduced by treatment with scopolamine at a concentration of 10^<-6> M, which showed no significant change in the long-term potentiation in a mossy fiber-CA3 system. These results suggest that vinconate may augment long-term potentiation in the mossy fiber-CA3 system partly via activation of the cholinergic system.

• 公益社団法人日本薬学会の論文
• 1994-07-15

著者

• 佐藤 公道

  Department of Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University

• 有田 健

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University

• 佐藤 公道

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University

• 荒木 勉

  Pharmacological Research Laboratory, Research Laboratories, Tokyo Tanabe Co.

• 主藤 克郎

  Pharmacological Research Laboratory, Research Laboratories, Tokyo Tanabe Co.

• 主藤 克郎

  Pharmacological Research Laboratory Research Laboratories Tokyo Tanabe Co.

• Satoh M

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• 佐藤 公道

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• 荒木 勉

  Pharmacological Research Laboratory Research Laboratories Tokyo Tanabe Co.

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