Production of LLU-α Following an Oral Administration of γ-Tocotrienol or γ-Tocopherol to Rats
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概要
- 論文の詳細を見る
An oral administration of γ-tocotrienol (γ-T3) or γ-tocopherol (γ-Toc) to male rats caused an increase of the concentration of 2,7,8-trimethyl-2-(β-carboxyethyl)-6-hydroxy chroman (LLU-α, γ-CEHC), a natriuretic compound, in plasma with a T_<max> of 9 h. The configuration at C-2 of LLU-α produced from γ-T3 or γ-Toc was assigned as S-form by an HPLC equipped with a chiral column. These data indicated that LLU-α was produced not only from γ-Toc but also γ-T3,without racemization at C-2 in rats.
- 公益社団法人日本薬学会の論文
- 2000-11-01
著者
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ABE Kouichi
Vitamin E Information and Technology Section, Eisai Co. Ltd.
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Fukushima Takeshi
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University
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IMAI Kazuhiro
Department of Bio-Analytical Chemistry, Graduate School of Pharmaceutical Sciences, The University o
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Hattori Akihiro
Department of Biomedical Information, Division of Biosystems, Institute of Biomaterials and Bioengin
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Imai Kazuhiro
Department Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences The University Of
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Imai Kazuhiro
Department Of Aeronautics And Astronautics School Of Engineering University Of Tokyo:(present Addres
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YOSHIMURA Hiroyuki
Food Additives & Chemical Division Eisai Co., Ltd.,
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Abe Kouichi
Vitamin E Information & Technology Section Eisai Co. Ltd.
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Hattori Akihiro
Department Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences The University Of
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Fukushima Takeshi
Department Of Bio-analytical Chemistry Graduate School Of Pharmaceutical Sciences The University Of
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Yoshimura Hiroyuki
Food Additives & Chemical Division Eisai Co. Ltd.
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