Inhibitory Effects of 5-S-GAD on Phosphorylation of V-SRC and BCR-ABL Tyrosine Kinase
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概要
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We examined the inhibitory effects of N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), a novel antibacterial substance from the immunized adult Sarcophaga peregrina (flesh fly), on protein phosphorylation using immune complexes of protein tyrosine kinases (PTKs) with anti-PTKs monoclonal antibody. We found that 5-S-GAD directly inhibited not only tyrosine phosphorylation of PTK p60^<v-src>, but also tyrosine phosphorylation of PTK p210^<BCR-ABL>. The inhibitory potency of 5-S-GAD was comparable to that of radicicol and herbimycin A of PTK inhibitor.
- 公益社団法人日本薬学会の論文
- 1998-07-15
著者
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Natori S
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Natori Shunji
Faculty Of Pharmaceutical Science The University Of Tokyo
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UEHARA Yoshimasa
National Institute of Infectious Diseases
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FUKAZAWA Hidesuke
National Institute of Infectious Diseases
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Park Ho
Korea Research Institute Of Bioscience And Biotechnology
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LEEN Jae
Korea Research Institute of Bioscience and Biotechnology
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Natori Shunji
Facult Of Parmaceutical Sciences The University Of Tokyo
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Leem Jae
Korea Research Institute of Bioscience and Biotechnology
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